Clinical Factors Related to Suspected Second Primary Lung Cancer Development in Patients with Head and Neck Cancer.
- Author:
Eui Bae KIM
1
;
Yong PARK
;
Seh Jong PARK
;
Dae Sik KIM
;
Jee Won KIM
;
Hee Yun SEO
;
Hwa Jung SUNG
;
In Keun CHOI
;
Kyong Hwa PARK
;
Sang Cheul OH
;
Chul Won CHOI
;
Byung Soo KIM
;
Yeul Hong KIM
;
Jun Suk KIM
;
Sang Won SHIN
;
Chul Yong KIM
;
Kwang Yoon JUNG
Author Information
1. Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. Sangwonshin@yahoo.com
- Publication Type:Original Article
- Keywords:
Chest x-ray;
Head and neck neoplasms;
Second primary cancer
- MeSH:
Academic Medical Centers;
Head;
Head and Neck Neoplasms;
Humans;
Incidence;
Korea;
Lung;
Lung Neoplasms;
Male;
Neoplasms, Second Primary;
Retrospective Studies;
Risk Factors;
Thorax
- From:Cancer Research and Treatment
2008;40(4):178-183
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The rate of second primary lung cancer development for patients with head and neck cancer (HNC) has been noted. The aim of our study was to evaluate the incidence and clinical features of suspected second primary lung cancer that developed in patients with primary HNC. MATERIALS AND METHODS: We conducted a retrospective study of 469 patients who were newly diagnosed with HNC at the Korea University Medical Center between January 2000 and December 2006. RESULTS: A total of 469 patients were included (389 men and 80 women). Eighteen patients (3.8%) had suspected second primary lung cancers. Statistically significant clinical variables for lung cancer development included the origin site for the primary HNC (oro-hypopharynx and larynx) (p=0.048), abnormal chest x-ray findings (p=0.027) and the histological HNC type (squamous cell carcinoma) (p=0.032). When the second primary lung cancers were combined with HNCs, the adjusted overall survival of patients with a second primary lung cancer was 16 months (p<0.001). CONCLUSIONS: Considering the relative risk factors for a second primary lung cancer developing in patients with HNC, advanced diagnostic tools, such as chest CT or PET CT scan, should be applied for the early detection of a second primary lung cancer.
