Expression of survivin in gastric carcinoma and analysis of its correlation with COX-2
- VernacularTitle:Survivin在胃癌中的表达及其与COX-2相关性的研究
- Author:
Junning ZHAO
;
Zhenyu ZHANG
;
Shiqi SUN
- Publication Type:Journal Article
- Keywords:
stomach neoplasms;
survivin;
COX-2;
immun ohistochemistry
- From:
China Oncology
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To detect the expression of a novel i nh ibitor gene of apoptosis,survivin,in gastric cancer and in gastric carcinoma MGC -803 cell line,also to analyze its correlation with the expression of COX-2. Methods:In 93 stomach carcinoma tissues and 20 normal gastric tissues , the expression o f survivin and COX-2 were examined by using the streptavidin-biotin peroxidase (SP) method. Results:In contrast to negative expression in normal gastric mucosa,survivin was express ed in 66 of 93(71%) cases of gastric cancer samples,Overexpression of survivin i n gastric carcinoma MGC-803 cell line was also found,There was a relationship b etween survivin gene expression and degrees of differentiation,lymph node metast ases and TNM stages.The expression of survivin was positively correlated with th at of COX-2(liner index of Pearson=0.227 P
