Expression of survivin gene in the dysplasia of gastric mucous epithelium and the gastric carcinoma and its significance
- VernacularTitle:胃粘膜异型增生和胃癌中Survivin基因的表达及相关性研究
- Author:
Haijun REN
;
Tianqing LIU
;
Xiaohui YU
- Publication Type:Journal Article
- Keywords:
dysplasia;
gastric mucosa;
gastric neoplasms;
survivin gene;
immunohistochemistry
- From:
China Oncology
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the expression of survivin a nd its relationship with the expression of bcl-2,p53,PCNA in the dysplasia of gastric mucous epithelium and gastric carcinoma.Methods:The expression of survivin,bcl-2,p53,PCNA was detected in 60 cases of gastric carcinoma, 30 cases of dysplasia of gastric mucous epithelim and 8 cases of normal gastric mucous tissue by using immunohistochemical SP method. Results:The positive rates of survivin were 10%,13%,80% and 82%, respectively, in mild, moderate and svere dysplasia and gastric carcinoma. The positive rates of survivin in mild and moderate dy splasia were significantly lower than in severe dysplasia and carcinoma (P0 05). There was a relationship between survivin gene expression with the invasive depth of gastric carcinoma. lymph node metastases and survival stage (P
