Expression and correlation of hTERT and p21(WAF1/CIP1) in colonic carcinoma
- VernacularTitle:结肠癌中hTERT、p21(WAF1/CIP1)的表达及二者相关性研究
- Author:
Lu LI
;
Jinyan LUO
;
Jin CHENG
;
Lei DONG
- Publication Type:Journal Article
- Keywords:
colonic carcinoma;
hTERT;
p21(WAF1/CIP1)
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expression and correlat ion of hTERT and p21(WAF1/CIP1) in colonic carcinoma. Methods A total of 45 cases of normal colonic carcinoma, 10 cases of colonic adenoma s and 10 cases of normal colonic tissues were studied using in situ hybridization (ISH) and immunohistochemical techniques. Results hTERT and p21 were found not only in colonic carcinoma (t he positive rate being 88.9% and 46.7%, respectively ), but also in colonic aden omas (the positive rate being 50.0% and 10.0%, respectively). The positive rate of hTERT expression increased significantly in advanced stage (C+D) of colonic c arcinoma ( P
