Expression and clinical significance of E-cadherin in colorectal carcinoma
- VernacularTitle:大肠癌E-钙黏附分子表达及其临床意义
- Author:
Hongjun WANG
;
Jincai CHEN
;
Rong WANG
- Publication Type:Journal Article
- Keywords:
E-cadherin;
colorectal carcinoma;
biological be havior
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between th e expression of E-cadherin (E-CD) and differentiation, macroscopic features, l ymph node metastasis, and Dukes stages of colorectal carcinoma (CC). Me thods Frozen storage samples of 31 cases of CC and adjacent normal c olon mucous membrane epithelium were examined for E-CD expression by S-P immun ohistochemistry. Results High expression of E-CD was detec ted in normal colorectal mucous membrane epithelium (100%) while E-CD expressio n was lower (77.4%) in the tumor samples. E-CD expression was closely associate d with the differentiations,macroscopic features and lymph node metastasis, resp ectively ( P 0.05). Conclusion The examination of E -CD expression can be used as a valuable index to evaluate the biological behav ior and prognosis of colorectal carcinoma.
