The expression and significant of CD44V6 and Bcl-2 in cervical carcinoma
- VernacularTitle:CD44V6,Bcl-2在宫颈癌中的表达及临床意义
- Author:
Xia LI
- Publication Type:Journal Article
- Keywords:
cervical carcinoma;
CD44V6 protein;
Bcl-2;
immun ohistochemistry
- From:Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of CD44V6 and Bcl-2 in cervical carcinoma and clinical significant in the progress of th is type of cancer. Methods A total of 153 cases of cervical carcinoma, normal cervical epithelium and cervical dysplasia were investigated for the expression of CD44V6 and Bcl-2 with immunohistochemistry SP method. Results ① The positive rate of CD44V6 was 69.44% in cervical carcinoma, 45.45% in cervical dysplasia and 8.33% in normal cervix epithelium ( P 0.05 )and pathological grades( P 0.05 ).Conclusion The overexpression of CD44V6 and Bcl-2 may be l inked to the pathogenesis, development and metastasis of cervical carcinoma. Det ermination of CD44V6 and Bcl-2 may be useful for properly estimating the progno sis of cervical carcinoma.
