Establishment of Osteosarcoma Models in Mice
- VernacularTitle:裸鼠人成骨肉瘤骨模型的建立
- Author:
Yongyu CHEN
- Publication Type:Journal Article
- Keywords:
bone neoplasms;
osteosarcoma;
monoclonal antiboty;
disease models, animal
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Human osteosarcoma cells (HOS-8603) cultured in vitro were injected into the medullary cavities of femur in 5 8-weeks aged NC nude mice and 5 6-weeks aged NC nude mice and in 7 of these animals human osteosarcoma grew. Osteolytic damage, parostium reaction and mass formation were observed on X-ray film. The pathologic findings in this study were similar to the characteristics of original tumor cells and AKP stain was positive.Anti-osteosarcoma monoclonal antibody labeled with 125I was used to carry out experimental guiding diagnostic study in these animal models with a high specificity.
