Cardiac functional affection by bone marrow stem cell transplanting after myocardial infarction
- VernacularTitle:骨髓干细胞移植对心肌梗死后左心室功能的影响
- Author:
Qing ZHOU
;
Congxin HUANG
;
Ruiqiang GUO
- Publication Type:Journal Article
- Keywords:
Echocardiography;
Myocardial infarction;
Hematopoietic stem cell transplantation;
Ventricular function,left
- From:Chinese Journal of Ultrasonography
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the rabbit cardiac siz e and cardiac function change before and after bone-marrow stem transplanting(BMST) by echocardiography.MethodsThirty-four rabbits were divided into 3 groups randomly: group control, group myocardial infarction(MI) and group BMST. The left anterior coronary artery in group MI and group BMST were ligated to produce the myocardial infarction model and injected bone-marrow stem cell to the infracted area in the later group. The size and the systolic function of the heart were measured before and after infarction and transplantation. The left ventricular systolic pressure (LVSP) and the end-diastolic pressure(LVEDP) were also measured in the 3 groups at the end of experiment. ResultsThe left ventricle diameter of group BMST was smaller than that of the group MI, and the ventricular function increased, and almost reached the normal level. And more, LVSP increased and LVEDP decreased statistically in the group BMST. ConclusionsBone-marrow stem transplantation can release the enlargement of left ventricle and improve cardiac function after myocardial infarction.
