Clinical analysis of patients with anorexia nervosa
- VernacularTitle:神经性厌食的临床分析
- Author:
Jieli LU
;
Yongju ZHAO
;
Jinfeng TANG
;
Liqun GU
;
Xiaohua JIANG
;
Ying YANG
;
Jie HONG
;
Jianmin LIU
;
Weiqing WANG
;
Bangyao LUO
;
Guang NING
- Publication Type:Journal Article
- Keywords:
Anorexia nervosa;
Amenorrhea;
Weight loss;
Hypothalamus;
Leptin
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To improve the awareness of clinical manifestation, endocrine changes and prognosis in patients with anorexia nervosa (AN). Methods The clinical features and endocrine functions of 28 patients with AN were analysed, and the prognosis was based on the results of 4 months-7 years follow-up of these patients. The change of serum leptin level was observed during different therapeutic periods in 13 patients. Results Most of AN patients were young women (92.9%, 26/28), age of onset was (19.4?3.8)years old and the duration of follow-up was from 4 months to 7 years. Self-starvation, extreme weight loss and amenorrhoea were the characteristic manifestations. This investigation discovered 24 patients with hypofunctional hypothalamus-pituitary-gonad axis, 12 with hyperfunctional hypothalamus-pituitary-adrenal axis, 9 with decreased levels of thyroid hormones, 2 with increased level of GH (n=10), 8 with decreased level of IGF-Ⅰ (n=10). Leptin levels in AN patients (n=9) weresignificantlydecreasedascomparedwiththecontrol group (n=26) 〔(1.21?0.36 vs 7.70?4.15)?g/L, P
