Dynamic comparison of specific antibody in the BALB/C mice infected with different dengue type 2 virus strains
- VernacularTitle:两株登革2型病毒感染BALBC小鼠特异性抗体产生动态的比较
- Author:
Zhengling SHANG
;
Li ZUO
;
Wenjie CHEN
;
Yu PAN
- Publication Type:Journal Article
- Keywords:
Dengue type 2 virus;
Virulence;
BALB/C mice;
Specific antibody
- From:
Chinese Journal of Immunology
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:BALB/C mice model infected with different Dengue Type 2 virus (DV 2) strains was evaluated and dynamic patterns of humoral immune responses caused by the various viral strains were investigated.Methods:The BALB/C mice were multisubcutaneouly injected by different DV 2 strains. The dynamic changes of the anti-DV 2 IgM/IgG antibody were observed in the infected BALB/C mice by the indrect ELISA and the viremia was observed.Results:The productions of specific antibodies in the infected BALB/C mice after primary and secondary injection with different DV 2 strains showed some difference. Howerer, BALB/C mice infected by the DV 2 B strain from a DHF patient showed the prolonged viremia.Conclusion:The dynamic curve of specific antibody and the viremia induced by various DV 2 strain (DV 2 NGC strain.V.DV 2 B strain) were different in some existence.
