Oxidized low density lipoprotein induces the human peripheral blood monocyte expression of proinflammatory cytokines mRNA
- VernacularTitle:OxLDL直接诱导人外周血单核细胞表达致炎细胞因子mRNA
- Author:
Xinjun LEI
;
Aiqun MA
;
Bingwen REN
;
Tao GENG
;
Wei ZHANG
- Publication Type:Journal Article
- Keywords:
Cytokine;
Monocyte;
Lipoprotein;
Atherosclerosis
- From:
Chinese Journal of Immunology
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the function of oxidized low density lipoprotein(OxLDL) in the formation of atherosclerotic immuno-pathological lesions in the local blood vessel.Methods:With the Digoxenin-labeled Oligonucleotide-probes In Situ Hybridization,studied the effects of OxLDL on the mRNA expression of proinflammatory cytokines including MCP-1, bFGF, PDGF and IL-10 in the human peripheral blood monocyte. Results:Monocyte was significantly increased the mRNA expression of MCP-1, bFGF, PDGF and IL-10 in a dose-dependent manner after incubating with OxLDL(10～30 mg/L)for 24 hours(P
