THE CLINICAL SIGNIFICANCE OF IgA ANTI-HBc IN VIRAL HEPATITIS B
- VernacularTitle:IgA抗-HBc检测对病毒性肝炎的临床意义
- Author:
Huiyu LIU
- Publication Type:Journal Article
- Keywords:
IgA anti-HBc,IgM anti-HBc Hepatitis B Diagnosis
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
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Abstract:
We have developed an antibody-captured sandwich-type enzyme linked immunosorbant assay(ELISA) with monoclonal anti-IgA/a (human) and monoclonal anti-HBc, and determined immunogloblin A against hepatitis B core antigendgA anti-HBc) in sera of 179 cases of various types of HBV infection. IgAanti-HBc in the patients with acute hepatitis B (14 cases) and severe hepatitis (7 cases) was all positive, while in the patients with chronic active hepatitis, cirrhosis, chronic persistent hepatitis, and symptomatic carriers the positive rates were 94% (47/50 cases), 83.3% (10/12 cases), 56.5%(26/46 cases) and 4%(2/50 cases), respectively. Our observations suggested that IgA anti-HBc may reflect hepatic damage in the patients with HBV infection. Its detection may be valuable in the diagnosis and prognosis HBV infection. In addition, the activity of IgA anti-HBc in chronic hepatitis B is related to HBeAg.
