Effects of ageing on the expression of peroxisome proliferator-activated recept or ? and the relation to insulin resistance
- VernacularTitle:老年大鼠过氧化体增殖物激活型受体-?的表达及其与胰岛素抵抗的关系
- Author:
Xiujin ZHANG
;
Ping YE
;
Zhaojun WANG
- Publication Type:Journal Article
- Keywords:
Peroxisome proliferators;
Insulin resistance
- From:
Chinese Journal of Geriatrics
1995;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of ageing on the expression of peroxisome proliferat or-activated receptor (PPAR)? and explore the relation with insulin resistance (IR).Methods Minimal model technique of Bergman was used to estimate the insulin sensitivity of young (10-12 weeks) and aged (24 months) SD rat. The PPAR?mRNA levels of omental fat were measured by reverse transcription-polymerase chain reaction(RT -PCR) and PPAR? protein level were determined by western blotting respectively . Results The level of IR in the aged group was significantly increased compared with tha t of the young group(IR: 11 49?6 92 vs 5 28?1 94,P
