The relationship between CAG polymorphisms of androgen receptor gene and prostate cancer in Chinese patients
- VernacularTitle:中国人群雄激素受体基因CAG多态性与前列腺癌关系的研究
- Author:
Hongwei LI
;
Jianhe LIU
;
Junqi WANG
- Publication Type:Journal Article
- Keywords:
Prostatic neoplasms;
Carcinoma;
Receptor, androgen;
Genes
- From:
Chinese Journal of Urology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the distributions of C AG polymorphisms of androgen receptor gene in Chinese population and the relatio nship with prostate cancer (CaP). Methods The number of CAG repeats were measured in 105 cases with CaP and 190 matched case-control b y PCR、DHPLC and Sequencing analysis,and its association with the susceptibility to CaP. Results The average number of CAG repeats was 2 2.7 in CaP and 23.3 in control group ( P =0.22).Men with CAG repeats lengt h less than 22 may be in high risk of prostate cancer (odds ratio,2.39;95%CI 1.1 9～4.81, P =0.012),compared with men CAG repeats length of 22 or more. Conclusions A less CAG repeat length (
