Microvessel density and expression of vascular endothelial growth factor in squa mous cell carcinomas of gingiva
- VernacularTitle:牙龈癌微血管密度及血管内皮生长因子表达的意义
- Author:
Dongmei LI
;
Yongxing CUI
;
Fusheng DONG
- Publication Type:Journal Article
- Keywords:
Vascular endothelial growth factor;
Angiogenesis;
Gingival;
Squamous cell neoplasms;
Metastasis
- From:
Journal of Practical Stomatology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the effects of angiogenesis in c ervical lymph node metastasis and progression of squamous cell carcinomas of gin giva (GSCC), and the distribution and expression of vascular endothelial growth factor (VEGF) in GSCC.Methods: Paraffin sections of surg ically obtained GSCC samples from 42 patients were stained with CD34 monoclon al antibody by immunohistochemical S P method to demonstrate blood vessels. Exp ression of VEGF was tested with the S P method, and the microvessel density (M VD) was determined according to the percent of the neoplastic cells showing VEG F immunoreactivity and the degree of staining.Results: The MVD in GSCC was significantly higher than that in normal gingival tissue( P 0.05). MVD in VEGF positive samples of GSCC was sig nificantly higher than that in VEGF negative ones ( P
