A molecular and genetical study of the source of Candida albicans in the mouth of neonates
- VernacularTitle:新生儿口腔中白色念珠菌来源的分子遗传学初探
- Author:
Xin ZENG
;
Qianming CHEN
;
Qing LI
- Publication Type:Journal Article
- Keywords:
Neonates;
Candida albicans;
Genotype
- From:
Journal of Practical Stomatology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the source of Candida alb ic ans in the mouth of neonates. Methods: 208 mother in fant pairs were recruited. Specimens from mothers for fungal culture were obtain de from the mouths by oral rinse and from vagina by swab within 48 h before de livery, and specimens from full term neonates were obtained from mouth by swab on the 1st, 3rd and 5th day while still in hospital and when the neonates were 1 month old. Candida species were identified by the routine microbiologica l methods, then Candida albicans isolated from mother infant pairs were com pared genetically by random amplified polymorphic DNA analysis (RAPD). Results: Candida albicans was isolated in the mouth of only 2 neonates (0.96%) and in the vagina and mouth of the corresponding 2 mothers in hospital.That was isola ted in the mouth of 43 neonates (21.39%) when they were 1 month old and in both vagina and mouth of 3 corresponding mothers and in the mouth of another 2 corr esponding mothers. RAPD revealed different genotypes of Candida albicans in each mother infant pair. Conclusions: The vertical tran smission of Candida albicans from mother to baby seems not to be the main so urce of Candida albicans in neonate mouth.
