SUSCEPTIBILITY OF VARIOUS STRAINS OF LABORATORY MICE TO LEISHMANIA DONOVANS INFECTION
- VernacularTitle:不同品系的小鼠对杜氏利什曼原虫感染的敏感性观察
- Author:
Yutang LI
- Publication Type:Journal Article
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
This paper deals with the susceptibility of 8 inbred and 1 outbred mouse strains infected with L. donovani. Each mice was inoculated intraperitoneally with 3?106, 9?106, 2?107 amastigotes and was killed on 29-30 th, 48-49 th, 58-59 th day after infection for examination respectively .Except one of C57BL strain received 3 ? 106 amastigotes,the results showed that all mice of 615 ,C57BL ,SMMC/C?615 strains became positive at autopsy with a highly intensive infection .The greater the amastigotes was inoculated,the havier the infection would be.The 3 strains, therefore, were susceptibility to acute infection of L.donovani.The other mouse strains failed to be infected(SMMC/B, SMMC/C, ICR/JCI and Kunming strains)or only showed mild infectons(SMMC/A and SMMC/D), indicating that these 6 mouse strains were relatively resistant to infection with the parasites. In the light of the origin of these mouse strains it seems that the genetic control is highly concerned in the host susceptibility to L. donovani.
