Advances in Vascular Prosthesis in Which Lined with Genetically Modified Endothelial Cells
- VernacularTitle:基因转染内皮细胞衬里人工血管的研究进展
- Author:
Yi DAI
;
Zhengrong QIAO
;
De SHI
- Publication Type:Journal Article
- Keywords:
Vascular prosthesis Gene therapy Endothelial cell
- From:
Chinese Journal of Bases and Clinics in General Surgery
2004;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the endothelial cell which was modified by exogenous anticoagulant genes contribute to the increase of antithrombosis activity of lined vascular prosthesis and the influence to other physiological functions of endothelial cells. Methods This summarized paper was made on literature review of recent years.Results The transfection of genes, including plasminogen activator (t-PA, u-PA, Urokinase), thrombomoduline (TM) and hirudin, etc, to endothelial cells resulted in not only the increase of antithrombosis activity of local vascular, but also the decrease of endothelial cell function in adherence and proliferation.Conclusion The increase of antithrombosis activity of lined vascular prosthesis has been done by exogenous genes. However, this technique ought to be studied, intensively.
