Research Advance of Relationship Between RET Proto-Oncogene and Differentiated Thyroid Carcinoma
- VernacularTitle:RET原癌基因与分化性甲状腺癌关系的研究进展
- Author:
Bo TANG
;
Jun JIANG
- Publication Type:Journal Article
- Keywords:
RET gene Thyroid carcinoma
- From:
Chinese Journal of Bases and Clinics in General Surgery
2004;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To review recent studies on the research advance of the relationship between RET proto-oncogene and differentiated thyroid carcinoma. Methods The literatures in recent years on the structure of RET gene and coding product,cell signal transduction,relationship between RET proto-oncogene and differentiated thyroid carcinoma were reviewed.Results RET gene encoding tyrosine kinase receptor,involving in cell signal transduction,rearrangement of RET gene was frequently seen in papillary thyroid carcinoma.Conclusion Rearrangement of RET gene was closely correlated with the occurrence and progress of differentiated thyroid carcinoma,RET gene may be considered as a new therapeutic target for differentiated thyroid carcinoma.
