FTY720 induces long-term survival of cardiac allograft in rats
- VernacularTitle:FTY720诱导大鼠心脏移植物长期存活
- Author:
Yongge ZHANG
;
Erwei SUN
;
Lei ZHANG
- Publication Type:Journal Article
- Keywords:
FTY720;
Heart transplantation;
Graft survival;
Rats
- From:
Chinese Journal of Organ Transplantation
2003;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of FTY720 on cardiac allograft survival in rats.Methods Wistar rats underwent abdominal heterotopic heart transplantation from SD rats and randomly divided into control group, CsA group, FTY720 group, MP group, FTY720+CsA group and FTY720+CsA+MP group.Results The number of peripheral blood lymphocytes in FTY720 group, FTY720+CsA group and FTY720+CsA+MP group was decreased at 3 h after administration, and recovered at 4th week. The median survival time in control group, CsA group, MP group and FTY720+CsA+MP group was 7.8 days, 16 days, 27.6 days and 16.8 days, but that in FTY720 group and FTY720+CsA group was respectively more than 150 days and 124 days.Conclusion FTY720 induces long-term survival of cardiac allograft in rats.
