Comparison of immunosuppression between demethylzeylasteral with Glucosidorum Tripterygll Totorum
- VernacularTitle:去甲泽拉木醛与雷公藤多甙的免疫抑制作用比较
- Author:
Zongming LIN
;
Chunxing YANG
;
Yongkang ZHANG
- Publication Type:Journal Article
- Keywords:
Tripterygium wilfordii;
Immunosuppressive agents;
Immunosuppression;
Drug evaluation
- From:
Chinese Journal of Organ Transplantation
2003;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the immunosuppression of Demethylzeylasteral (T-96) on the lymphocytic blastogenesis in vitro and compare the inhibitory effects on the rejection in renal transplant rats between T-96 with Glucosidorum Tripterygll Totorum (TII) in vivo. Methods Mixed lymphocyte cells were cultured through xenogenous antigen to stimulate C57BL/6 mouse spleen cell blast transformation, then different concentrations of T-96 or TII were added respectively. By 3H-TdR methods, the inhibitory effects of T-96 and TII on the blast transformation of spleen cells were measured. Different doses of T-96 or TII were given for different groups of renal transplant rats to evaluate the effects on survival time of renal transplant rats.Methods At the concentrations of 0.25 , 0.5 , 1.0 ??g/ml T-96, there was a significant inhibitory effect on the blast transformation of mouse spleen cells as compared with control group ( P
