Effect of Zhongjiling tablet on IFN-?,IL-4,TGF-? in experimental autoimmune my- asthenia gravis(EAMG) rat
- VernacularTitle:中药重肌灵片体内对EAMG大鼠IFN-?、IL-4、TGF-?水平的影响
- Author:
Jing WANG
;
Yong ZHOU
;
Xudan WANG
;
Tao HAN
;
Dongyu GE
- Publication Type:Journal Article
- Keywords:
Experimental autoimmune myasthenia gravis;
Zhongjiling Tablet;
IFN-?;
IL-4;
TGF-?
- From:
Chinese Journal of Immunology
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore cytokine mechanism of Zhongjiling Tablet therapy to experimental autoimmune myasthenia gravis (EAMG). Methods: Lewis rats were immunized with N2-AChR(from Torpedo's electrical organ)in CFA. ELISA were adopted to determine IFN-?,IL-4,TGF-? levels in serum and surpernatant fluids and anti-N2-AChR total IgG,IgG1,IgG2 titers in serum of EAMG on week 7 post immunization and treatment.Results:In serum and surpernatant fluids:IFN-?,IL-4 level in model group were dramatically higher than CEA group ( P
