The effect of irbersartan on the osteopontin and MCP-1 expression in lipid-induced renal injury
- VernacularTitle:厄贝沙坦对脂质肾损害大鼠骨调素和单核细胞超趋化蛋白表达的影响
- Author:
Rui WANG
;
Ruhan JIA
;
Hongyan LIU
;
Changjian QIU
- Publication Type:Journal Article
- Keywords:
Receptors, angiotensin;
Hypercholesterolemia;
Monocyte chemoattractant proteins;
Macrophages
- From:
Chinese Journal of Geriatrics
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of osteopontin(OPN) and monocyte chemoattractant protein-1(MCP-1) and the effect of Irbersartan on them in diet-hypercholesterolemia rats. Methods Wistar rats were divided into three groups: normal control rats(C), cholesterol fed rats(H) and cholesterol fed rats treated with Irbesartan(50 mg ? kg -1 ? d -1 ). Twelve weeks later, we measured the 24 hours total urine protein, creatinine clearance and total serum cholesterol, LDL- cholesterol, HDL- cholesterol and triglycerides. Kidney pathology was observed. Immunohistochemistry was used to analyse the expression of OPN, MCP-1, ED1 +and their relationship. Results (1) Total serum cholesterol, LDL-cholesterol level and 24 h total urine protein in H group rats were higher than that in C group rats, there was no significant difference between two groups in HDL-cholesterol and triglycerides.(2) Compared with C group rats , the expression of OPN and MCP-1 increased in cortical tubular epithelium (2.34?0.25 vs 0.49?0.11; 1.93?0.21 vs 0.49?0.11, P
