Effects of high-fat diet on insulin sensitivity in rats
- VernacularTitle:高脂饮食诱发大鼠胰岛素抵抗的实验研究
- Author:
Yicun YIN
;
Dajin ZOU
- Publication Type:Journal Article
- Keywords:
insulin resistance;
high-fat diet;
troglitazone;
endothelin-1
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of high-fat diet on insulin sensitivity in rats. Methods Normal rats were fed with equicalorical high-fat diet and then treated with troglitazone. Glucose-insulin tolerance test was used to measure insulin sensitivity, blood pressure, blood glucose, insulin, endothelin, lipid, tissue glycogen and triglyceride levels. Results high-fat diet had no effect on body weight gain and blood pressure. Fasting and postprandial blood glucose levels were similar among the different groups. The levels of blood insulin, triglyceride, cholesterol and endothelin increased markedly, and the decrease in tissue glycogen level was also found. high-fat feeding caused insulin resistance after 4 weeks (K 5.63 vs. control 7.77, P
