Analysis of HLA-A, B local haplotype among Han population in Northwest China
- VernacularTitle:西北地区汉族HLA-A ,B基因座单元型分析
- Author:
Hongbo ZHANG
;
Jianghua LAI
;
Junhai ZHAO
;
Shuping LAI
- Publication Type:Journal Article
- Keywords:
HLA-A local;
HLA-B local;
haplotype;
linkage disequilibrium;
Han population
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the HLA-A, B local haplotype frequencies of Han population in Northwest China. Methods The results of HLA-A, B local polymorphism were obtained by using the PCR-sequence specific oligonucleotide probes (SSOP) reverse dot blot. Haplotype was inferred by the heredity law of HLA. Results The high haplotype frequencies were A02-B46, A30-B13, A02-B40. Linkage disequilibrium parameters of 11 haplotypes had significant differences. Conclusion The HLA-A, B local haplotype frequencies of Han population in Northwest China differ from those of Han population in other areas. The haplotypes A30-B13, A01-B37 and A32-B44 present significant linkage disequilibrium.
