The analgesic effect of interleukin-2 in the neuropathic pain mice
- VernacularTitle:白细胞介素-2对小鼠神经病理性痛的镇痛作用
- Author:
Junyang WANG
- Publication Type:Journal Article
- Keywords:
interleukin-2;
analgesia;
neuropathic pain;
mouse
- From:Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the analgesic effect and possible mechanisms of interleukin-2(IL-2) on the neuropathic pain,and to screen the novel drug for neuropathic pain diseases.Methods Male C57BL/6 mice whose unilateral L5/L6 spinal nerves were ligated were used as a neuropathic pain model.The pain thresholds of paw ipsilateral to the nerve injury before and after intraperitoneal(i.p.) injection of different doses of IL-2(1.0?10~(6)u/kg,2.5?10~(6)u/kg and 5.0?10~(6)u/kg) were measured by the mechanical and cold stimuli.Opioid receptor antagonist naloxone(1mg/kg),30min prior to the administration of 5.0?10~(6)u/kg of IL-2,was given to investigate the influence of naloxone on the analgesic effect induced by IL-2.Results IL-2 produced dose-dependent analgesic effect.Both 5.0?10~(6)u/kg and 2.5?10~(6)u/kg of IL-2 significantly increased the 50% paw withdrawal threshold((P
