The role of SR-BI in the human peripheral blood monocyte expression of proinflammatory cytokines mRNA induced by oxidized low density lipoprotein
- VernacularTitle:SR-BI在OxLDL诱导人血单核细胞表达致炎细胞因子mRNA中的作用
- Author:
Xinjun LEI
;
Aiqun MA
;
Tao GENG
;
Ling BAI
;
Wei ZHANG
- Publication Type:Journal Article
- Keywords:
scavenger receptor;
cytokine;
monocyte;
lipoprotein;
fucoidin;
estrogen;
atherosclerosis
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the function of scavenger receptor class B type I(SR-BI)in the human peripheral blood monocyte expression of proinflammatory cytokines mRNA induced by oxidized low density lipoprotein(OxLDL). Methods With the digoxenin-labeled oligonucleotide-probes in situ hybridization, we investigated the effects of OxLDL, fucoidin and 17?-estradiol on the primarily-cultured human peripheral blood monocyte mRNA expression of SR-BI and relationship between its expression and the mRNA expressions of MCP-1, bFGF, PDGF and IL-10. Results The mRNA expression of SR-BI was significantly increased in a dose-dependent manner after incubating with OxLDL (10～30 mg?L -1)(P
