Survivin ,P21~(WAF1/CIP1),Cyclin D1 proteins expression in cervical carcinoma:correlations with recurrence of early stage cervical cancer of the uterus
- VernacularTitle:Survivin、P21~(WAF1/CIP1)及Cyclin D1蛋白表达及与早期宫颈癌复发的关系
- Author:
Quanhong LI
;
Jiafi YAO
;
Shumin HU
- Publication Type:Journal Article
- Keywords:
cervical carcinoma;
survivin;
P21WAF1/CIP1;
Cyclin D1;
recurrent;
immunohistochemistry
- From:
China Oncology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the expression of Survivin,P21 WAF1/CIP1 and CyclinD1 proteins in cervical carcinoma and to investigate their relation to recurrence of early stage cervical cancer of the uterus.Methods:Using streptavidin-biotin peroxidase (sp) method,we examined the protein expression of Survivin, P21 WAF1/CIP1 and Cyclin D1 in 55 cervical carcinomas (45 cervical squamous carcinomas and 10 cervical adenocarcinomas ) and 10 normal cervical tissues.Results:① The positive rates of Survivin,Cyclin D1,P21 WAF1/CIP1 were 0,10.0%,20.0% in normal cervical tissue,and 68.9%,51.1%,57,8% in cervical squamous carcinomas,and 60.0%,90.0%,80.0% in cerrical adenocarcinomas respectively. There were significant differences in the positive results of Survivin,CyclinD1,P21 WAF1/CIP1 between normal cervical tissue and cervical cancer ( P 0.05).③The coexpression of Survivin with P21 WAF1/CIP1 or CyclinD1 were both associated with higher tumor grade( P
