Advances in research on relationship between mitochondrial genome and tumor
- VernacularTitle:线粒体基因组与肿瘤的相关性研究进展
- Author:
Xiaohong LIU
;
Minghua ZHU
- Publication Type:Journal Article
- Keywords:
mitochondrial DNA;
tumor;
mutation
- From:
China Oncology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondria play important roles in cellular energy metabolism,free radical generation and apoptosis. Mitochondrial dysfunction is one of the most profound features of cancer cells. Several distinct differences between the mitochondria of normal cells and cancer cells have been observed at the molecular,biochemical,metabolic and genetic levels. In this article,we review the relationship between mitochondrial DNA (mtDNA) and carcinogenesis of cancer cells. The possible mechanisms are also discussed.
