Tumor Angiogenesis and Dynamic Contrast-enhanced MR Imaging in Non-small Cell Lung Cancer:Imaging-Pathologic Correlation
- VernacularTitle:非小细胞肺癌肿瘤血管生成与动态增强MRI表现的相关性
- Author:
Wei XING
;
Chunhong HU
;
Xiaoying ZHANG
;
Liang GUO
;
Yi DING
- Publication Type:Journal Article
- Keywords:
pulmonary carcinoma;
magnetic resonance imaging;
angiogenesis;
vascular endothelial growth factor
- From:
Journal of Practical Radiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of dynamic contrast-enhanced (DCE) MRI features with microvessel density (MVD) and vascular endothelial growth factor (VEGF) in non-small cell lung cancer(NSCLC).Methods Conventional MR imaging and dynamic contrast-enhanced scan in thirty-three patients with NSCLC confirmed by pathologyn were performed. MVD and VEGF were stained with immuno-histochemical technique in all cases. Some parameters of DCE MRI, including maximum slope(Smax) and time to peak(TTP) were put more analysis. The relationship between the results of DCE MRI (Smax and TTP) and that of immuno-histochemistry (MVD and VEGF) was analysed.Results The Smax of adeno carcinoma was higher than that of squamous cell carcinoma,but TTP was lower. The difference was obvious difference(t=3.22,P
