Screening out nasopharyngeal carcinoma by two-stage ELISA for EB virus
- VernacularTitle:两阶段EB病毒酶联免疫吸附法筛查鼻咽癌的探讨
- Author:
Weimin CHENG
;
Mingfang JI
;
Xiaoling LI
- Publication Type:Journal Article
- Keywords:
EBV;
Serology;
Nasopharyngeal carcinoma;
Human
- From:
Chinese Journal of Immunology
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Screening out NPC from susceptable crowd by serological test for EB virus.Methods:Checking antibody of EB virus by ELISA. At first, EBNA1 IgA was detected for susceptable crowd as a primary screening index, secondary , EBNA1 IgG and Zta IgG were detected in the EBNA1 IgA positive group.Results:The sensitivity and specificity of EBNA1 IgA were 91.8% and 91.4%, both were higher than those of EBNA1 IgG and Zta IgG; the sencondary detection of EBNA1 IgG and Zta IgG raised the specificity of NPC screening to 96.5% and also helped to divide the crowd into 3 groups as high, median, and low risk. And the high risk group accounted for 0.39%.Conclusion:Two-stage screening of NPC raise the sensitivity and specificity of NPC detection. It also helps to divide the crowd into 3 groups of risk.
