The effect of bispecific antibody(BsAb,anti-human bladder cancer/anti-VEGF) on cancer bearing mice
- VernacularTitle:抗人膀胱癌/抗VEGF双功能基因抗体导入治疗荷瘤鼠膀胱癌的研究
- Author:
Ming REN
;
Lucheng LIU
;
Haitao FAN
- Publication Type:Journal Article
- Keywords:
Bispecific antibody;
Microvessel density;
Immunohistochemistry
- From:
Chinese Journal of Immunology
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the inhibitory role of BsAb(anti-human bladder cancer/anti-VEGF) on human bladder cancer growth.Methods:BsAb was used to treat animal models of BIU-87 cell lines.The tumor inhibition rate was calculated and the tumor microvessel density was detected by immunohistochemical techniques.Results:BsAb could significantly inhibit growth of tumor.And the tumor microvessel density was lower than that of the control group.Conclusion:BsAb could inhibit tumor growth by inhibiting angiogenesis. BsAb may become a new method for human bladder cancer treatment.
