Research advances in drug transporters and multidrug resistance
- VernacularTitle:药物转运蛋白和多药耐药性的研究进展
- Author:
Zhiyu CHEN
;
Ligong XU
- Publication Type:Journal Article
- Keywords:
multidrug resistance;
drug transporter;
neoplasm
- From:
China Oncology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Multidrug resistance (MDR) is the most common cause in the failure of cancer chemotherapy. Drug transporters play an important role in multidrug resistance in cancer. Activation of drug pumps which belong to ATP-binding cassette (ABC) transporters leads to the efflux of drug via cell membrane.Three subgroups of ABC transporters are involved in the transport of cytotoxic drugs.These transporters include ABCB subgroup,ABCC subgroup and ABCG subgroup. In this review,the author discussed the recent research advances in the ABC transporters associated with MDR.
