Effect of verapamil on ischemic random skin flaps in rats
- VernacularTitle:维拉帕米在大鼠缺血随意皮瓣中作用的研究
- Author:
Li ZHUANG
;
Yeguang SONG
- Publication Type:Journal Article
- Keywords:
Surgical flaps;
Verapamil;
Rats, wistar
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effect of verapamil on the i schemic random skin flaps. MethodsThe dorsal random skin flap s of Wistar rats were raised (length/width=6/1). Verapamil was injected under th e flaps at the dose of 25mg/kg after the operations. Seven days later, the necro sis rate, the content of molondialehyde (MDA) in middle segment and the microsco pic observation were studied. ResultsThe necrosis rates were 1 5.9 % in verapamil group and 21.8 % in control group. The content of MDA in midd le segment of verapamil group was 164.8 nmol/L, and that in control group was 19 5.8 nmol/L. The difference was very significant. Under the microscope, the tissu e inflammatory reactions in the experiment group were not so severe as that in t he control group. ConclusionVerapamil improves the survival of the ischemic random skin flaps and it is applicable to give verapamil by subcut aneous injection.
