Effects of vitamines on human preadipocyte proliferation and differentiation
- VernacularTitle:常用维生素对人前脂肪细胞增殖和分化的作用
- Author:
Xiaohai ZHU
;
Qinglian HE
;
Zihao LIN
- Publication Type:Journal Article
- Keywords:
Vitamins;
Adipocytes;
Cell differentiation
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the effects of vitamins on human pr eadipocyte proliferation and differentiation. MethodsVit amins (A, B, C, D, E and K families) were added to the culture media of human p readipocytes, then the proliferation of cells, the expression of GPDH and lipid droplet accumulation in the cytoplasm were recorded. ResultsVitamin A inhibited human preadipocyte proliferation and differentiation. Vi tamin C enhanced differentiation and proliferation. Vitamin B 6 stimulated diff erentiation. vitamin D 3 inhibited differentiation. Vitamin E had a strong inhi bitory effect on human preadipocyte differentiation. Vitamin K 1 had an unexpec tedly great stimulatory effect on human preadipocyte differentiation. Vitamin K 3 inhibited both human preadipocyte proliferation and differentiation. Other v itamins tested showed no noticeable effects. ConclusionT hese data are advisory to our balanced daily intake of vitamins.
