The effects of transfection of a truncated BMP-II receptor on the prolife ration of Tca8113 cells
- VernacularTitle:转染BMP-II型突变受体基因对Tca8113舌癌细胞增殖的影响
- Author:
Fu SHENG
;
Jin YAN
;
Liu YUAN
- Publication Type:Journal Article
- Keywords:
Bone morphogenetic protein;
Tca8113 cell;
Recepto r;
ransfection;
Proliferatio
- From:
Journal of Practical Stomatology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effects of BMPs signals on the proliferation of tongue cancer Tca8113 cells. Methods: Th e cDNA of truncated BMP-II receptor was transfected into Tca8113 cells by usin g FuGENE6 transfection kit, the transfected cells were named Tca8113ZR. The pro liferation and DNA synthesis of Tca8113 and Tca8113ZR cells were investigated b y MTT assay,FCM and BrdU analysis. Results: In MTT assay the A value of Tca8113 and Tca8113ZR cells was 0.47?0.01 and 0.35?0.01 (P0.05).Conclus ion: BMPs might be involved in the development of squamous cell carc inoma of tongue.
