A PRELIMINARY PATHOLOGICAL STUDY OF IgA NEPHROPATHY-LIGHT-AND ELECTRON MICROSCOPIC OBSERVATION
- VernacularTitle:免疫球蛋白A肾病病理形态学的初步研究(附150例肾活检光镜及电镜观察)
- Author:
Taihe ZHANG
- Publication Type:Journal Article
- Keywords:
immunoglobulin A Nephropathy
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
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Abstract:
In this study, renal biopsy specimens from 150 cases of IgA nephropathy were studied with light-and electron microscopically. Histological lesions from minimal change to diffuse mesangial proliferation were observed. According to the degree of the renal lesions, the 150 cases were divided into 6 subtypes. Proliferation of mesangial matrix was found to be the striking ultrastructural alteration, which often appeared as focal segmental or global proliferation of mesangial cells, as well as marked increase in mesangial matrix. Electron-dense deposits were largely localized in mesangial matrix and in suben dothelial regions. However, no positive correlation could be seen between the number of the deposits and the degree of the lesions.
