Study of learning and memory function in D-galactose model mice improved by Sanchi Saponin Rg1 and its participating factors
- VernacularTitle:三七皂甙Rg1改善D-半乳糖模型鼠学习记忆能力与其作用的可能因素
- Author:
Ping QIAO
;
Guizhen YANG
- Publication Type:Journal Article
- Keywords:
D-galactose;
Index of intracellular calcium apoptosis;
IL-6;
IL-1?
- From:
Chinese Journal of Immunology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the role of sanchi Saponin Rg1 in D-galactose -induced amnesic mice ,and its possible mechanism.Methods:D-galactose was injected by subcutaneous to establish the aging model, and with drug treatment group.The Y-maze tests was performed to evaluate the learning and memory function, spectrophotometry was used to measure abilities of anti-oxidation.ELISA was adopted to evaluate the level of IL-1? and IL-6. Then FCM was applied to assay the index of intracellular calcium and the percentage of neural cell apoptosis.Results:Compared with drug treatment group, the model mice reduced significantly activites of anti -oxidation , the overload of intracelluer calcium and the increase in apoptosis of neural cells as well as the inflammation factor.Conclusion:Sanchi Saponin Rg1 decreased in the content of inflammation factor , the index of intracellular calcium and the percentage of apoptosis in neural cells , possibly by enchancing the antioxidant function.
