Regression of left ventricular hypertrophy with ramipril and losartan:assessment by three-dimensional echocardiography
- VernacularTitle:三维超声心动图评价高血压左心室肥厚消退治疗的临床研究
- Author:
Rui XU
;
Yun ZHANG
;
Mei ZHANG
- Publication Type:Journal Article
- Keywords:
Echocardiography,three-dimensional;
Hypertension;
Hypertrophy,left ventricular
- From:
Chinese Journal of Ultrasonography
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the reduction in left ventricular hypertrophy (LVH) caused by monotherapy with ramipril or losartan or the combination of these two drugs,in patients with hypertensive LVH and to evaluate the value of three-dimensional echocardiography (3DE) on LVH regression.Methods Ninety-six essential hypertensive patients with LVH were enrolled in this study.All patients were randomly divided into 3 groups: ramipril group,losartan group,combination group with ramipril and losartan.Left ventricular mass(LVM) was calculated by M-mode echocardiography,two-dimensional echocardiography and 3DE at baseline and after 6 months treatment with ramipril or losartan.Results Of 96 patients enrolled,59 patients have complete follow-up datum.LVM of ramipril,losartan and combination group decreased 16.9% , 17.9% and 18.8% compared with before treatment.LVM by 3DE decreased 11.6% , 14.7% and 13.6% respectively.The difference of LVM derived from 3DE showed obviously lower than derived from M-mode echocardiography.Conclusions Applying M-mode echocardiography and two-dimensional echocardiography to evaluate the regression of LVH will overestimate the effects of drugs.Three-dimensional echocardiography may detect the changes of LVM more accurately.
