Relativity Study on Genotoxicity and Lipid Peroxidation of Organic Chemical Pollutants in Water of Huaihe River on Mice
- VernacularTitle:淮河水有机提取物对小鼠遗传毒性和脂质过氧化作用
- Author:
Ying ZHUANG
;
Chengmei JIANG
;
Hong ZHAO
- Publication Type:Journal Article
- Keywords:
Water pollution,chemical;
Mutagenicity test;
Lipid peroxidation
- From:
Journal of Environment and Health
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the related factors effecting the genotoxicity and lipid peroxidation of organic ex-tracts from source water of Huaihe River and its tap water on mice.Methods XAD-II resin was used to absorb the organic chemical pollutants in source water and tap water.The mice were exposed to organic extracts through peritoneal injection continuously for5days.The micronucleus test,the sperm deformity test,the determination of the activities of SOD and GSH-Px and the concentrations of LPO in serum,liver and brain of mice were carried out.Results The fre-quncies of micronuclei and abnormal sperm of mice exposed to organic extracts at dosage of0.01ml/1g(bw)corre-sponding to100L/kg(bw)source water,finished water and tap water increased significantly compared with those of controls(P
