Effect of ischemia on donor coronary arteries after heart transplantation
- VernacularTitle:缺血对移植心脏冠状血管的影响
- Author:
Feng QIU
;
Wangfu ZANG
;
Hai TIAN
- Publication Type:Journal Article
- Keywords:
Heart transplantation;
Coronary vessels;
Myocardial ischemia
- From:
Chinese Journal of Organ Transplantation
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between Cardiac allograft vasculopathy (CAV) and donor heart ischemia time. Methods The rat model of retroperitioneal heterotopic heart transplantation was used. Seventy Wistar rats were divided into 4 groups: group 1 receiving CsA after sham operation; group 2 receiving transplantation directly; group 3 having 3 h-ischemia before transplantation; group 4 having 6?h ischemia before transplantation. After transplantation, all rats in each group were subjected to the gastric lavage of CsA for 20?days. At 20?days after transplantation, the donor heart was removed for observation of changes in pathological lesions and ultrastructues of coronary artery. Results With ischemia time being prolonged, cardiac capillary endothelial cell swelling and coronary intimal proliferation were observed which were similar to the CAV histopathological changes. Conclusion The prolongation of ischemia time can lead to intimal proliferation and hyperplasia which can promote CAV development. So ischemia time is a vital reason for the CAV.
