A transmission electron microscopic study on biological reaction of synovitis in duced by wear particles from joint prosthesis
- VernacularTitle:假体磨损颗粒诱导关节滑膜生物反应的电镜观察
- Author:
Dingwei SHI
;
You WANG
;
Zhenan ZHU
- Publication Type:Journal Article
- Keywords:
Joint prosthesis;
Biological reaction;
Cells;
Wear pa rticle
- From:
Chinese Journal of Trauma
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the cytological mechanism of bi ological reaction of prosthetic loosening mediated by wear particles from joint prosthesis. Methods Three special particles of UHMWPE, Ti- 6Al-4V and Co-Cr-Mo with the same average size of 2.5 ?m were injected respe ctively into rabbit knee joint to induce synovitis, in which the changes of syno vial cells and its cytoplasm as well as ultrastructure were observed by transmis sion electron microscopy. Results Three kinds of particles mainly induced type A synovial cell reaction with proliferation of subsynovial h istocytes. Wear particles and lysosomes existed in the cytoplasms of the synovia l cells and histocytes. Co-Cr-Mo particles could also accelerate infiltrating reaction of regional cytoplasms. Conclusions The biological effect of wear particles inducing prosthetic loosening is mainly non-immunolog ic inflammatory reaction. Certain immunologic factors may involve in biological reaction induced by Co-Cr-Mo wear particles.
