Prostaglandin E_2 induces osteoblast bone formation in aged male rats
- VernacularTitle:前列腺素E_2促进老年大鼠成骨细胞骨形成及其机制研究
- Author:
Liao CUI
;
Tie WU
- Publication Type:Journal Article
- Keywords:
Prostaglandin E 2;
Osteoblasts;
Osteogenesis
- From:
Chinese Journal of Geriatrics
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the early effects of prostaglandin E 2 (PGE 2 ) on cancellous bone in 20-month aged male rats. Methods PGE 2 was given to the aged rats for 10 and 30 days at dose of 3 mg?kg -1 d -1 respectively, while designing intact aged male rats as controls. After twice in vivo fluorochrome labeling, undecalcified longitudinal sections were subjected to analysis of bone histomorphometry. Results After 10 days treatment, osteoblast surface 〔(12.3?7.6)%〕 and osteoid surface 〔(20.4?7.2)%〕 were markedly increased than that of controls 〔(1.6?0.7)% and (4.3?1.7)%, P
