Protein expressions of insulin receptor substrates of adipose tissue and their significance in the type 2 diabetic patients
- VernacularTitle:胰岛素受体底物在2型糖尿病患者脂肪组织中的表达及意义
- Author:
Dingqiong PENG
;
Yu CHEN
;
Yan GAO
;
Xiaohui GUO
- Publication Type:Journal Article
- Keywords:
Insulin receptor substrate-1;
Insulin receptor substrate-2;
Diabetes mellitus, non-insulin-dependent;
Insulin resis tance
- From:
Chinese Journal of Endocrinology and Metabolism
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The levels of protein expressions o f insulin receptor substrate-1 and -2 (IRS-1 and IRS-2) in abdominal subcuta neous adipose tissue from type 2 diabetic patients were measured by Western blot technique. The expression of IRS-1 protein was reduced and the expression of I RS-2 protein was unchanged in adipose tissue of type 2 diabetic patients. IRS- 2 may be the main docking protein and one of the factors causing hyperinsulinemi a and insulin resistance in type 2 diabetes mellitus.
