Association of urinary transforming growth factor- ?_1, laminin and type Ⅳ collagen with diabetic nephropathy in type 2 diabetic patients
- VernacularTitle:尿TGF-?_1、层粘连蛋白、Ⅳ型胶原与2型糖尿病肾病的关系
- Author:
Wenhuan FENG
;
Xin GAO
;
Zhen YE
;
Dawang WANG
;
Jingchen ZHENG
;
Zhihua TAO
;
Jianbo WU
;
Feixia SHEN
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, non-insulin-depend ent;
Diabetic nephropathies;
Transforming growth factor-? 1;
Laminin;
Collage n, type Ⅳ
- From:
Chinese Journal of Endocrinology and Metabolism
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Urinary excretions of transforming grow th factor-? 1 (TGF-? 1), laminin (LN) and type Ⅳ collagen were determined i n 182 type 2 diabetic patients. Urinary excretions of TGF-? 1, LN and type Ⅳ collagen were increased in type 2 diabetic patients, and these findings were fa irly well correlated with severity of diabetic nephropathy (DN). Urinary TGF-? 1 seems to be the early index of DN, urinary LN and type Ⅳ collagen appear to be the indices of DN severity.
