Establishment of a network pharmacokinetic model for multiple component drugs and parameter analyses
- VernacularTitle:多成分药物代谢网络动力学数学模型建立及参数分析
- Author:
Fuyuan HE
- Publication Type:Journal Article
- Keywords:
multiple component network pharmacokinetics;
whole compartmental model;
mathematical model;
Laplace transform;
pharmacokinetics
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To establish a network pharmacoki- netic model for studying multiple drug components and analyzing their parameters.METHODS:A model has been set up based on the compartment and linear kinetic theories,and the solutions have been obtained by Laplace transform method.The relations between the whole comp- artment model and network model for multiple component have been comparatively studied and their kinetic parame- ters have also been estimated and analyzed.RESULTS: The multiple component network pharmacokinetics follow a first order linear mammillary model.C_i is a polynomial of power index number e,which is similar to the whole compartment model.Various parameters(transit constant) were calculated by the expression of matrix consisting of?_i and the compartment parameters.Its kinetic parameters can be obtained on the basis of the whole compartment model.CONCLUSION:The multiple component net- work pharmacokinetic parameters can be obtained and an- alyzed similarly as the whole compartment model.
