A preliminary study of the immunotherapy of dendritic cells transfected with mRNA of gastric cancer cells in carried-tumor mice and its exosomes
- VernacularTitle:致敏树突细胞及exosome对胃癌的免疫治疗作用研究
- Author:
Zhibin LUO
;
Caipu XU
;
Guiyin SUN
- Publication Type:Journal Article
- Keywords:
Dendritic cells;
Gastric cancer;
TIDC;
Exosome;
mice
- From:
Chinese Journal of Immunology
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Our previous result showed unravel the functional status of DC in the tissue of gastric cancer (GC) and precancerous lesions, and probed into the possibility of preventing solid carcinoma such as GC.Methods:In the experiment of immunotherapy for the tumor-bearing mice,treated by DC sensitized by mRNA of gastric acncer cells.Results:The indices such as the production rate of ascites of mice(75%),the metastasis rate of tumor(25%),the survival rate of animals (75%) and the average weight of trmor(2.04?0.33 g)showed that the condition of the mice treated by DC was better than that in the control group(P
