Th1/Th2 type cytokines expression in peripheral blood cell of the patients with hepatitis B virus infection and its clinical significance
- VernacularTitle:乙型肝炎患者外周血细胞中Th1/Th2型细胞因子的表达及其临床意义
- Author:
Maohua ZHOU
;
Ding WANG
;
Jianjun ZHANG
- Publication Type:Journal Article
- Keywords:
Flow cytometry;
Th1/Th2 type cytokine;
Hepatitis B;
Immune response
- From:
Chinese Journal of Immunology
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the Th1/Th2 type cytokines expression and its clinical significance in various clinical behaviors of HBV-infected individuals.Methods:The production of IFN-? and IL-4 by CD3+CD8+?CD3+CD8-cells in peripheral blood from normal donor and patients with hepatitis B virus infection were assessed by a four-color flow cytometry.Results:Compared with the healthy control,the percentage of Tc1 cells in AHB group was higher,whereas the percentage of Th1 and Tc1 cells in CHB group were lower,and lower than that of the AHB,but they increased significantly with the chronic hepatic inflammation activity.Conclusion:T-helper 1 type cytokines are predominant in peripheral blood cell of AHB and CHB,but the different percentage of Th1 type cytokines may be one reason of the final outcome of the HBV-infected individuals.
