Effects of almitrine-raubasine on learning-memory ability in chronic episodic hypoxia rat and possible biochemical mechanism involved
- VernacularTitle:阿米三嗪-萝巴新对慢性间断性缺氧大鼠学习记忆能力的改善及相关生化机制的探讨
- Author:
Yan XU
;
Shunwei LI
;
Pingping ZUO
;
Lingna KONG
- Publication Type:Journal Article
- Keywords:
Hypoxia,brain;
Memory;
Choline O-acetyltransferase;
Almitrine;
Yohimbine
- From:
Chinese Journal of Neurology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of almitrine-raubasine on learning-memory ability and brain choline acetyltransferase (ChAT) activity in chronic episodic hypoxia (EHYP) rat. Methods After establishing the rat model of EHYP, almitrine-raubasine (0.03 tablets/250 g body weight , Bid) was given to the EHYP rats. The learning-memory ability was evaluated by using passive avoidance test and the ChAT activity in three different brain regions (including cerebral cortex, hippocampus and striatum) was determined using radiochemical method. Results As compared with the controlled rats, the performance on passive avoidance test of EHYP rats was impaired significantly (P
