A Case of Hyalinizing Spitz Nevus: A Rare Variant in the Spectrum of Spitz Nevus.
- Author:
Ik Jun MOON
1
;
Hyun Ji KANG
;
Woo Jin LEE
;
Chong Hyun WON
;
Sung Eun CHANG
;
Jee Ho CHOI
;
Miwoo LEE
Author Information
1. Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. miumiu@amc.seoul.kr
- Publication Type:Case Report
- Keywords:
Biopsy;
Differential diagnosis;
Histology;
Hyalinizing Spitz nevus
- MeSH:
Adult;
Biopsy;
Coloring Agents;
Diagnosis;
Diagnosis, Differential;
Female;
Humans;
Hyalin*;
Nevus;
Nevus, Epithelioid and Spindle Cell*;
S100 Proteins;
Vimentin
- From:Korean Journal of Dermatology
2017;55(3):195-197
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hyalinizing Spitz nevus was first introduced in 1994 by Suster. It is considered a rare variant in the spectrum of Spitz nevus, with only a dozen cases having been reported to date. Herein we report a case of a 28-year-old Korean woman who had a brown papular lesion on the left palm, which was diagnosed as hyalinizing Spitz nevus. Upon histopathological investigation, discohesive growth patterns of nevus cells in a hyalinized stroma were noted. Immunohistochemical stains showed positive reactivity of nevus cells with S-100 protein and vimentin, but negative stains with HMB-45 and CD68. This case demonstrates a rare variant of Spitz nevus located on an unusual site, and calls for awareness in the diagnosis of cutaneous lesions that histologically exhibit a prominent hyalinized stroma.
